| タイトル | Changes in glucose, insulin, and growth hormone levels associated with bedrest |
| 著者（英） | Rambaut, P. C.; Goodwin, A. L.; Leach, C. S.; Vernikos-Danellis, J.; Winget, C. M. |
| 著者所属（英） | NASA Ames Research Center|NASA Johnson Space Center |
| 発行日 | 1976-06-01 |
| 言語 | eng |
| 内容記述 | Changes in plasma glucose, insulin, and growth hormone (HGH) resulting from exposure to 56 d of bedrest were determined in five healthy young male subjects. Changes in the daily levels of these factors for each subject were expressed as the mean of six blood samples per 24-h period. The level of HGH dropped after 10 d of bedrest, then showed a 1.5-fold increase at 20 d and subsequently decreased gradually reaching levels of 2.5 mg/ml/24 h, well below pre-bedrest controls of 4.2 mg/ml/24 h, by the 54th d. In spite of a marked increase in the daily plasma insulin levels during the first 30 d of bedrest, glucose levels remained unchanged. Beyond 30 d of bedrest, insulin began decreasing toward pre-bedrest levels and glucose followed with a similar reduction to below the control levels of 75 mg/100 ml/24 h on day 54. The daily mean changes reflect a change in the amplitude of the diurnal variation. The daily peak in plasma insulin shifted progressively to the late evening during the bedrest period. |
| NASA分類 | AEROSPACE MEDICINE |
| レポートNO | 76A37062 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/442656 |
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