タイトル | Comparative distribution of the trace elements Sc, Mn, Fe, Co, Zn, Se, Rb, and Zr in the brain and other organs of C57BL/6N mice |
その他のタイトル | C57BL/6Nマウスの脳およびその他器官内の微量元素Sc、Mn、Fe、Co、Zn、Se、Rb、およびZrの比較分布 |
著者(日) | 大石 茂雄; 天野 良平; 西田 真樹; 米林 朋子; 安東 醇; 榎本 秀一; 安部 文敏 |
著者(英) | Oishi, Shigeo; Amano, Ryohei; Nishida, Maki; Yonebayashi, Tomoko; Ando, Atsushi; Enomoto, Shuichi; Anbe, Fumitoshi |
著者所属(日) | 理化学研究所; 理化学研究所; 金沢大学 医学部 保健学科; 金沢大学 医学部 保健学科; 金沢大学 医学部 保健学科; 理化学研究所; 理化学研究所 |
著者所属(英) | Institute of Physical and Chemical Research; Institute of Physical and Chemical Research; Kanazawa University School of Health Sciences, Faculty of Medicine; Kanazawa University School of Health Sciences, Faculty of Medicine; Kanazawa University School of Health Sciences, Faculty of Medicine; Institute of Physical and Chemical Research; Institute of Physical and Chemical Research |
発行日 | 1998-03-31 |
刊行物名 | RIKEN Accelerator Progress Report, 1997 理化学研究所加速器年次報告 1997 |
巻 | 31 |
開始ページ | 127 |
刊行年月日 | 1998-03-31 |
言語 | eng |
抄録 | Multitracer technique has been applied to the study of biobehavior of Sc, Mn, Fe, Co, Zn, Se, Rb and Zr trace elements in normal C57BL/6N mice. The tissue distribution of the eight elements was examined among 11 organs and blood, and evaluated in terms of tissue uptake rate. Preparation process of no-carrier-added radioactive multitracer solution for injection use was described. Procedures for the intraperitoneal injection of the solution into the mice and for the measurement of blood and tissue samples were presented. Tissue uptake rates of trace elements have been measured. All the eight radioactive tracers were observed in the cardiac muscle, lung, liver, spleen, pancreas and kidneys. As far as the uptake rate of Fe is concerned, it was found to be negligibly low in the brain, muscle and testes, on the contrary, be significantly high in the kidney, liver, pancreas and spleen. It was estimated that the transportation rates of Fe tracer to brain, muscle and testes are considerably slower than those to kidneys, liver, pancreas and spleen due to the difference in the transport mechanism. C57BL/6N正常マウス体内でのSc、Mn、Fe、Co、Zn、Se、Rb、およびZrの微量元素の生体挙動の研究に多重トレーサ手法を適用した。8元素の生体内分布を11器官および血液を対象に調べ、生体内取込み率で評価した。マウスへの注射用の担体無添加の放射性多重トレーサ溶液の調製法を記述した。マウスへの溶液の腹腔内注射方法および血液と生体組織試料の測定方法を述べた。微量元素の生体内取込み率を測定した。8種の放射性トレーサすべてを心筋、肺、肝臓、ひ臓、すい臓、腎臓で観測した。Feの取込み率に関しては、脳、筋肉、精巣では極めて少なく、反対に腎臓、肝臓、すい臓、ひ臓では著しく高いことが分かった。輸送メカニズムの違いにより腎臓、肝臓、すい臓、ひ臓への輸送速度に比べて、脳、筋肉、精巣へのFeトレーサの輸送速度はかなり遅いと推定した。 |
キーワード | trace element distribution; multitracer solution; radioactive trace element; biobehavior; tissue distribution; tissue uptake rate; intraperitoneal injection; normal mouse; transportation mechanism; 微量元素分布; 多重トレーサ溶液; 放射性微量元素; 生体挙動; 生体内分布; 生体内取込み率; 腹腔内注射; 正常マウス; 輸送メカニズム |
資料種別 | Technical Report |
ISSN | 0289-842X |
SHI-NO | AA0001362119 |
URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/44499 |
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