| タイトル | Prostaglandin control of renal circulation in the unanesthetized dog and baboon |
| 著者（英） | Vatner, S. F.; Swain, J. A.; Boettcher, D. H.; Heyndrickx, G. R. |
| 著者所属（英） | Peter Bent Brigham Hospital|Peter Bent Brigham Hospital|New England Regional Primate Research Center|Childrens Hospital Medical Center|Harvard Univ. |
| 発行日 | 1975-09-01 |
| 言語 | eng |
| 内容記述 | Effects of indomethacin and meclofenamate, inhibitors of prostaglandin synthesis, were evaluated in the regulation of renal blood flow in conscious and anesthetized dogs and in tranquilized baboons, instrumented with arterial pressure catheters and renal blood flow probes. Indomethacin, 10 mg/kg, did not alter renal blood flow or resistance significantly in the conscious dog. In the anesthetized dog, however, indomethacin caused a reduction in renal blood flow and an elevation of renal vascular resistance. Meclofenamate, 4 mg/kg, reduced renal flow and increased renal vascular resistance in conscious dogs. In conscious dogs and tranquilized primates, indomethacin and meclofenamate reduced the reactive hyperemia in the renal bed. Methoxamine and angiotensin II infused in graded doses induced significantly greater renal vasoconstriction in conscious dogs in the presence of indomethacin. Thus, in the conscious animal, prostaglandins appear to play only a minor part in the control of renal circulation at rest, but they are of greater importance in mediating the renal responses to reactive hyperemia and to vasoconstriction. |
| NASA分類 | LIFE SCIENCES (GENERAL) |
| レポートNO | 76A10098 |
| 権利 | Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/445303 |
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