Role of the tonically active neurons of the primate's striatum on the adaptive motor control

Abstract

The neostriatum is an input structure in the basal ganglia, large subcortical nuclei in the brain, and has long been implicated in motor planning and motor learning. It has been demonstrated that the tonically active neurons in the striatum are presumably cholinergic giant aspiny interneurons and acquire conditioned sensory responses during conditioning. This acquisition of the response requires dopaminergic input from the substantia nigra. The neurons were found mainly in the matrix of the striatum, especially in the border regions of the striosmes, suggesting a role on sensory-motor integration during motor learning.

線条体は脳内にある脳幹神経節、大きい皮質下核内の入力組織であり、長い間運動計画と運動学習に関係してきた。線条体内の緊張活性ニューロンは、コリン作用性巨大アスピン介在ニューロンと推定され、条件づけの間に条件感覚応答を習得する。この応答取得には黒質からのドーパミン作用性入力を必要とする。このニューロンは、主として線条体の基質内、特に運動学習中の感覚-運動統合に関する役割を示す線条の境界領域に見られた。