| タイトル | Down-regulation of connexin 43 mRNA in mouse hearts after myocardial infarction |
| その他のタイトル | 心筋梗塞後のマウスの心臓におけるコネクシン43 mRNAのダウンレギュレーション |
| 著者（日） | 竹村 春起; 安井 健二; 丹羽 統子; 北條 真弓; 堀場 充; Lee, Jong-Kook; 上田 裕一; 児玉 逸雄 |
| 著者（英） | Takemura, Haruki; Yasui, Kenji; Niwa, Noriko; Hojo, Mayumi; Horiba, Mitsuru; Lee, Jong-Kook; Ueda, Yuichi; Kodama, Itsuo |
| 著者所属（日） | 名古屋大学 大学院医学研究科; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野; 名古屋大学 大学院医学研究科; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野 |
| 著者所属（英） | Nagoya University Graduate School of Medicine; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function; Nagoya University Graduate School of Medicine; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function |
| 発行日 | 2003-12 |
| 刊行物名 | Environmental Medicine
Environmental Medicine |
| 開始ページ | 37 |
| 終了ページ | 38 |
| 刊行年月日 | 2003-12 |
| 言語 | eng |
| 抄録 | Gap junction remodeling have been reported in various types of heart disease. Information available for the gap junction remodeling after myocardial infarction is still limited. In the present study, investigated was mRNA expression of connexin 43 (Cx43), major protein of gap junction channels in compensated hypertrophied interventricular septum (IVS) after myocardial- infarction (MI) in mice by using a real time quantitative PCR expression. Cx43 mRNA expression in the interventricular septum of MI mouse was significantly decreased by 2 fold (813.7 +/- 252.6 molecules/10(exp 5) GAPDH molecules) compared to non-operated control (1,628.9 +/- 180.9) and sham-operated mice (2,051.9 +/- 169.8). There was no significant difference in Cx43 mRNA between control and sham groups. Down-regulation of Cx43 mRNA in compensated hypertrophied myocardium could be involved in the arrythmogenic substrate in the heart after MI. |
| キーワード | mouse; heart; mRNA; myocardial infarction; hypertrophy; connexin 43; gap junction; down-regulation; マウス; 心臓; mRNA; 心筋梗塞; 肥大; コネクシン43; ギャップ結合; ダウンレギュレーション |
| 資料種別 | Technical Report |
| ISSN | 0287-0517 |
| SHI-NO | AA0046450009 |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/47825 |
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