| タイトル | Distribution of ZAKI-4 in neurons of mouse cerebral cortex |
| その他のタイトル | マウス大脳皮質ニューロンにおけるZAKI-4の分布 |
| 著者（日） | 早坂 静; 星野 伸; Siddiq, Ayesha; 加納 安彦; 高岸 芳子; 神部 福司; 妹尾 久雄; 村田 善晴 |
| 著者（英） | Hayasaka, Shizu; Hoshino, Shin; Siddiq, Ayesha; Kano, Yasuhiko; Takagishi, Yoshiko; Kanbe, Fukushi; Seo, Hisao; Murata, Yoshiharu |
| 著者所属（日） | 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野; 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野; 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野; 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野; 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野; 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野; 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野; 名古屋大学環境医学研究所 分子・細胞適応部門 発生・遺伝分野 |
| 著者所属（英） | Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation; Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation; Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation; Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation; Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation; Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation; Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation; Research Institute of Environmental Medicine, Nagoya University Dept. of Teratology and Genetics, Division of Molecular and Cellular Adaptation |
| 発行日 | 2001-12 |
| 刊行物名 | Environmental Medicine
Environmental Medicine |
| 巻 | 45 |
| 号 | 1 |
| 開始ページ | 29 |
| 終了ページ | 31 |
| 刊行年月日 | 2001-12 |
| 言語 | eng |
| 抄録 | ZAKI-4 was identified as a product of thyroid hormone responsive gene cloned from cultured human skin fibroblasts. A recent in vitro study revealed that ZAKI-4 belongs to a family of proteins that inhibit calcineurin function. Though ZAKI-4 mRNA is known to be expressed abundantly in brain, the subcellular distribution of ZAKI-4 protein is still not known. Here the localization of ZAKI-4 in the mouse brain was investigated using immunohistochemistry. It was revealed that ZAKI-4 was distributed in neurons of the brain. Immunoelectron microscopy showed that ZAKI-4 was mainly localized in the cytoplasm of soma, but not in nuclei nor organella such as mitochondria or endoplasmic reticulum. Since the cellular localization of ZAKI-4 in neurons overlaps with that of calcineurin, it is postulated that ZAKI-4 exerts a calcineurin inhibitory effect in neurons of the mouse brain in vivo. |
| キーワード | ZAKI-4; mRNA; mouse; neuron; gene expression; immunohistochemistry; cellular distribution; skin fibroblast; ZAKI-4; mRNA; マウス; ニューロン; 遺伝子発現; 免疫組織化学; 細胞分布; 皮膚線維芽細胞 |
| 資料種別 | Technical Report |
| ISSN | 0287-0517 |
| SHI-NO | AA0032700007 |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/51105 |
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