| タイトル | Experiment K-7-29: Connective Tissue Studies |
| 著者（英） | Ilyina-Kakueva, E. I.; Burkovskaya, T. E.; Reddy, B. R.; Festoff, B. W.; Rayford, A. R.; Rao, J. S. |
| 著者所属（英） | Kansas Univ. |
| 発行日 | 1994-09-01 |
| 言語 | eng |
| 内容記述 | In zero or micro-gravity, type 1 muscle fibers atrophy and lose predominance, especially in slow-twitch muscles. No increase in mononuclear cells has been observed, just as in simple denervation, where both types 1 and 2 fibers atrophy, again without infiltration of cells, but with clear satellite cell proliferation. However, extracellular matrix (ECM) degradation takes place after denervation and if re-innervation is encouraged, functional recovery to near control levels may be achieved. No information is available concerning the ECM milieu, the activation of serine proteases, their efficacy in degrading ECM components and the production of locally-derived natural protease inhibitors (serpins) in effecting surface proteolytic control. In addition, no studies are available concerning the activation of these enzymes in micro- or zero gravity or their response to muscle injury on the ground and what alterations, if any, occur in space. These studies were the basis for the experiments in Cosmos 2044. |
| NASA分類 | Life Sciences (General) |
| レポートNO | 96N29600 |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/542731 |
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