| タイトル | High Salt Intake Promotes Urinary Loss of Vitamin D Metabolites by Dahl Salt-Sensitive Rats in a Space Flight Model |
| 著者（英） | Sayavongsa, P.; Clark, T.; Cephas, S.; Arnaud, S. B.; Thierry-Palmer, M. |
| 著者所属（英） | Morehouse School of Medicine|NASA Ames Research Center |
| 発行日 | 2004-05-05 |
| 言語 | eng |
| 内容記述 | Vitamin D metabolism in the Dahl salt-sensitive (S) rat, a model of salt-induced hypertension, differs from that in the Dahl salt-resistant (R) rat. We have demonstrated that female S rats are more vulnerable than female R rats to decreases in plasma 25-hydroxyvitamin D (25-OHD) and 1,25-dihydroxyvitamin D (1,25-(OH)2D) concentrations during hind limb unloading (a space flight model). We report here on the response of the vitamin D endocrine system of S and R rats to hind limb unloading during high salt intake. Dahl female rats (9.7-week-old) were tail-suspended (hind limb unloaded) for 28 days, while fed a diet containing twice the salt in standard rat chow (2 % sodium chloride). Control rats were fed the same diet, but were not hind limb unloaded. Vitamin D metabolites were analyzed by HPLC and radioimmunoassay kits from Diasorin. |
| NASA分類 | Life Sciences (General) |
| レポートNO | Rept-04-A-179-ASBMR |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/543620 |
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