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タイトルThe difference of mRNA expression of ATP-sensitive K(+) channel subunits in embryonic and adult mouse heart
その他のタイトルATP感受性K+チャネルサブユニットのmRNA発現におけるマウスの胚性と成体心臓における相違
著者(日)安井 健二; 北條 真弓; 児玉 逸雄
著者(英)Yasui, Kenji; Hojo, Mayumi; Kodama, Itsuo
著者所属(日)名古屋大学環境医学研究所 器官系機能調節部門 循環器分野; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野; 名古屋大学環境医学研究所 器官系機能調節部門 循環器分野
著者所属(英)Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function; Research Institute of Environmental Medicine, Nagoya University Department of Circulation, Division of Regulation of Organ Function
発行日2003-12
刊行物名Environmental Medicine
Environmental Medicine
開始ページ35
終了ページ36
刊行年月日2003-12
言語eng
抄録ATP-sensitive K+(K(sub ATP)) channels is expressed in early-stage embryonic heart as well as at the adult stage. K(sub ATP) channels are composed of pore-forming (Kir) and regulatory sulfonylurea receptor (SUR) subunits. Studied was mRNA expression of Kir6.1, Kir6.2, SUR1, SUR2A, SUR2B and SUR2C mRNAS encoding for K(sub ATP) channels in cardiac ventricles of embryonic (9.5 days postcoitum, dpc) and adult mice using RT-PCR. 30 cycles of PCR revealed mRNA expression of all genes at the adult-stage. At 9.5 dpc, Kir6.1 mRNA was undetectable, whereas mRNAS of other subunits were expressed. At 9.5 dpc, SUR2A expression was higher than SUR1 and SUR2B. In the adulthood, mRNAs of all subunits were detected. This finding suggests that Kir6.2 is dominant pore-forming subunit from an early embryonic stage. The developmental changes of transcriptional profile of K(sub ATP) channels may underlie the different functional properties of the channel in pre- and post-natal period.
キーワードgene expression; mRNA expression; ATP; potassium ion channel; mouse; embryo; heart; 遺伝子発現; mRNA発現; ATP; カリウムイオンチャネル; マウス; 胚; 心臓
資料種別Technical Report
ISSN0287-0517
SHI-NOAA0046450008
URIhttps://repository.exst.jaxa.jp/dspace/handle/a-is/55697


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