| タイトル | Individual Variability in Sensorimotor Network Functional Connectivity Correlates With the Rate of Early Visuomotor Adaptation |
| 本文（外部サイト） | http://hdl.handle.net/2060/20160001026 |
| 著者（英） | Mulavara, A.; DeDios, Y.; Ruitenberg, M.; Bloomberg, J.; Riascos, R.; Seidler, R.; Kofman, I.; Wood, S.; Koppelmans, V.; Cassady, K.; Reuter-Lorenz, P.; Gadd, N. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2016-04-24 |
| 言語 | eng |
| 内容記述 | Sensorimotor adaptation is a type of procedural motor learning that enables individuals to preserve accurate movements in the presence of external or internal perturbations. Adaptation learning can be divided into an early, more cognitively demanding stage, and a later, more automatic stage. In recent years, several investigations have identified significant associations between sensorimotor adaptation and brain structure and function. However, the question of whether individual variability in functional connectivity strength is predictive of sensorimotor adaptation performance has been largely unaddressed. In the present study, we investigate whether such variability in early sensorimotor adaptation is associated with individual differences in resting-state functional connectivity. We used resting state functional magnetic resonance imaging (rs-fMRI) to estimate functional connectivity strength using hypothesis-driven (seed-to-voxel) and hypothesis-free (voxel-to-voxel) approaches. For the hypothesis-driven analysis, we selected several regions of interest (ROIs) from sensorimotor and default mode networks of the brain. We then correlated these connectivity measures with the rate of early learning during a visuomotor adaptation task in 16 healthy participants. For this task, participants lay supine in the MRI scanner and moved an MRI-compatible dual axis joystick with their right hand to hit targets presented on a screen. Each movement was initiated from the central position on the display screen. Participants were instructed to move the cursor to the target as quickly as possible by moving the joystick, and to hold the cursor within the target until it disappeared. They were then instructed to release the joystick handle after target disappearance, allowing the cursor to re-center for the next trial. Performance was assessed by measuring direction error (DE), defined as the angle between the line from the start to the target position, and the line from the start to the position at peak velocity. Each participant's rate of learning was determined by calculating the slope of DE across adaptation trials. This slope was used as the primary outcome measure for the rate of early adaptation. Seed-to-voxel results revealed that bilateral putamen and bilateral insular cortex connectivity strength were correlated with the rate of early adaptation, such that faster learners exhibited greater connectivity strength than slower learners. Furthermore, voxel-to-voxel results indicated that left insular cortex connectivity and right postcentral gyrus connectivity were correlated with the rate of early adaptation, such that faster learners exhibited greater connectivity strength within left insular cortex and weaker connectivity strength within right postcentral gyrus. These results demonstrate that the learning rate in an early adaptation task is associated with sensorimotor network functional connectivity strength. The findings from this study provide novel insights into the neural processes underlying individual variability in early sensorimotor adaptation. |
| NASA分類 | Behavioral Sciences |
| レポートNO | JSC-CN-35096 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/558042 |
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