| タイトル | Spaceflight Effects on Neurocognitive Performance: Extent, Longevity and Neural Bases |
| 本文（外部サイト） | http://hdl.handle.net/2060/20160001037 |
| 著者（英） | Seidler, R. D.; Riascos-Castaneda, R. F.; Bloomberg, J. J.; Wood, S. J.; Szecsy, D. L.; Kofman, I. S.; Mulavara, A. P.; Cassady, K.; De Dios, Y. E.; Koppelmans, V. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2016-02-08 |
| 言語 | eng |
| 内容記述 | We are conducting ongoing experiments in which we are performing structural and functional magnetic resonance brain imaging to identify the relationships between changes in neurocognitive function and neural structural alterations following a six month International Space Station mission and following 70 days exposure to a spaceflight analog, head down tilt bedrest. Our central hypothesis is that measures of brain structure, function, and network integrity will change from pre to post intervention (spaceflight, bedrest). Moreover, we predict that these changes will correlate with indices of cognitive, sensory, and motor function in a neuroanatomically selective fashion. Our interdisciplinary approach utilizes cutting edge neuroimaging techniques and a broad ranging battery of sensory, motor, and cognitive assessments that will be conducted pre flight, during flight, and post flight to investigate potential neuroplastic and maladaptive brain changes in crewmembers following long-duration spaceflight. Success in this endeavor would 1) result in identification of the underlying neural mechanisms and operational risks of spaceflight-induced changes in behavior, and 2) identify whether a return to normative behavioral function following re-adaptation to Earth's gravitational environment is associated with a restitution of brain structure and function or instead is supported by substitution with compensatory brain processes. Our preliminary findings document brain structural volumetric increases, primarily restricted to sensorimotor regions. Eventual comparison to our bed rest study results will enable us to parse out the multiple mechanisms contributing to any spaceflight-induced neural structural and behavioral changes that we observe as we accumulate more data. In this presentation I will discuss our progress to date with the flight study |
| NASA分類 | Aerospace Medicine; Life Sciences (General) |
| レポートNO | JSC-CN-35071 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/558518 |
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