| タイトル | Long Duration Head Down Tilt Bed Rest Effects on Neurocognitive Performance: Extent, Longevity and Neural Bases |
| 本文（外部サイト） | http://hdl.handle.net/2060/20160001036 |
| 著者（英） | Wood, S. J.; Kofman, I. S.; Seidler, R. D.; Koppelmans, V.; Yuan, P.; Szecsy, D. L.; Riascos-Castaneda, R F.; De Dios, Y. E.; Mulavara, A. P.; Cassady, K. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2016-02-08 |
| 言語 | eng |
| 内容記述 | We are conducting ongoing experiments in which we are performing structural and functional magnetic resonance brain imaging to identify the relationships between changes in neurocognitive function and neural structural alterations following a six month International Space Station mission and following 70 days exposure to a spaceflight analog, head down tilt bedrest. Our central hypothesis is that measures of brain structure, function, and network integrity will change from pre to post intervention (spaceflight, bedrest). Moreover, we predict that these changes will correlate with indices of cognitive, sensory, and motor function in a neuroanatomically selective fashion. Our interdisciplinary approach utilizes cutting edge neuroimaging techniques and a broad ranging battery of sensory, motor, and cognitive assessments that will be conducted preflight, during flight, and post flight to investigate potential neuroplastic and maladaptive brain changes in crewmembers following long-duration spaceflight. Success in this endeavor would 1) result in identification of the underlying neural mechanisms and operational risks of spaceflight-induced changes in behavior, and 2) identify whether a return to normative behavioral function following re-adaptation to Earth's gravitational environment is associated with a restitution of brain structure and function or instead is supported by substitution with compensatory brain processes. In this presentation I will provide an overview of changes in behavior, brain structure, and brain function that we are observing in our bed rest participants in comparison to normative control subjects. |
| NASA分類 | Behavioral Sciences; Aerospace Medicine |
| レポートNO | JSC-CN-35072 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/558519 |
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