Flavan-3-ol類の位置選択的修飾法の開発

Abstract

There is currently great interest in the investigation of flavan-3-ols from food sources that have strong biological activities, as these compounds are generally considered highly safe because we take them as a part of food in daily diet. However, the structure-activity-relationships (SARs) of flavan-3-ols are not well understood because they are obtained as a mixture of various analogs in many cases, which makes purification difficult. So, we developed regioselective modification method of flavan-3-ols. Recently we reported a new synthesis strategy of galloyl group modified flavan-3-ols by regioselevtive deprotection at 5-position. Here we demonstrated the details of the reaction conditions of our method and recent further investigation.