| タイトル | Analysis by NASA's VESGEN Software of Retinal Blood Vessels Before and After 70-Day Bed Rest: A Retrospective Study |
| 本文（外部サイト） | http://hdl.handle.net/2060/20160002099 |
| 著者（英） | Parsons-Wingerter, Patricia A.; Vyas, Ruchi J.; Taibbi, Giovanni; Zanello, Susana B.; Vizzeri, Gianmarco; Ploutz-Snyder, Robert; Raghunandan, Sneha |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 2016-02-08 |
| 言語 | eng |
| 内容記述 | Significant risks for visual impairment associated with increased intracranial pressure (VIIP) are incurred by microgravity spaceflight, especially long-duration missions. Impairments include decreased near visual acuity, posterior globe flattening, choroidal folds, optic disc edema and cotton wool spots. We hypothesize that microgravity-induced fluid shifts result in pathological changes within the retinal blood vessels that precede development of visual and other ocular impairments. Potential contributions of retinal vascular remodeling to VIIP etiology are therefore being investigated by NASAs innovative VESsel GENeration Analysis (VESGEN) software for two studies: (1) head-down tilt in human subjects before and after 70 days of bed rest, and (2) U.S. crew members before and after ISS missions. VESGEN analysis in previous research supported by the US National Institutes of Health identified surprising new opportunities to regenerate retinal vessels during early-stage, potentially reversible progression of the visually impairing and blinding disease, diabetic retinopathy. |
| NASA分類 | Aerospace Medicine |
| レポートNO | ARC-E-DAA-TN29564 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
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