| タイトル | The BioSentinel Bioanalytical Microsystem: Characterizing DNA Radiation Damage in Living Organisms Beyond Earth Orbit |
| 本文（外部サイト） | http://hdl.handle.net/2060/20160007343 |
| 著者（英） | Schooley, A.; Lusby, T.; Padgen, M.; Swan, B. G.; Mousavi, A.; Parra, M.; Gavalas, S.; Marina, D.; Lewis, B.; Hanel, R.; Chartres, J.; Tan, M.; Rademacher, A.; Klamm, B.; Bhattacharya, S.; Defouw, G.; Gentry, D.; Benton, J.; Sanchez, H.; Wheeler, S.; Santa Maria, S.; Friedericks, C.; Boone, T.; Ricco, A. J. |
| 著者所属（英） | NASA Ames Research Center |
| 発行日 | 2016-06-05 |
| 言語 | eng |
| 内容記述 | We will present details and initial lab test results from an integrated bioanalytical microsystem designed to conduct the first biology experiments beyond low Earth orbit (LEO) since Apollo 17 (1972). The 14-kg, 12x24x37-cm BioSentinel spacecraft (Figure 1) assays radiation-responsive yeast in its science payload by measuring DNA double-strand breaks (DSBs) repaired via homologous recombination, a mechanism common to all eukaryotes including humans. S. cerevisiae (brewer's yeast) in 288 microwells are provided with nutrient and optically assayed for growth and metabolism via 3-color absorptimetry monthly during the 18-month mission. BioSentinel is one of several secondary payloads to be deployed by NASA's Exploration Mission 1 (EM-1) launch vehicle into approximately 0.95 AU heliocentric orbit in July 2018; it will communicate with Earth from up to 100 million km. |
| NASA分類 | Aerospace Medicine; Space Radiation |
| レポートNO | Paper ID No 0092
ARC-E-DAA-TN30932 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
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