| タイトル | Fibroblast Growth Factor 23 in Long-Duration Spaceflight |
| 本文（外部サイト） | http://hdl.handle.net/2060/20150001900 |
| 著者（英） | Fields, E.; Heer, M.; Sibonga, J.; Zwart, S. R.; Bokhari, R.; Smith, S. M. |
| 著者所属（英） | NASA Johnson Space Center |
| 発行日 | 2015-01-13 |
| 言語 | eng |
| 内容記述 | Many nutritional factors influence bone, from the basics of calcium and vitamin D, to factors which influence bone through acid/base balance, including protein, sodium, and more. Fibroblast growth factor 23 (FGF23) is a recently identified factor, secreted from osteocytes, which is involved in classic (albeit complex) feedback loops controlling phosphorus homeostasis through both vitamin D and parathyroid hormone (PTH) (1, 2). As osteocytes are gravity sensing cells, it is important to determine if there are changes in FGF23 during spaceflight. In extreme cases, such as chronic kidney disease, FGF23 levels are highly elevated. FGF23 imbalances, secondary to dietary influences, may contribute to skeletal demineralization and kidney stone risk during spaceflight. |
| NASA分類 | Life Sciences (General); Aerospace Medicine |
| レポートNO | JSC-CN-32718 |
| 権利 | Copyright, Distribution as joint owner in the copyright |
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