| タイトル | Anti-Macrophage Migration Inhibitory Factor Antibody Suppresses Chronic Rejection of Heterotopically Transplanted Trachea in Rats |
| 本文（外部サイト） | http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/9360/1/acta51_02_51.pdf |
| 参考URL | http://hdl.handle.net/10069/9360 |
| 著者（英） | Sumida, Yorihisa; Yamashita, Hideki; Inoue, Masao; Ohsawa, Kazutaka; Sato, Hiroshi; Nanashima, Atsushi; Nagayasu, Takeshi |
| 発行日 | 2006-06 |
| 刊行物名 | Acta medica Nagasakiensia |
| 巻 | 51 |
| 号 | 2 |
| 開始ページ | 51 |
| 終了ページ | 56 |
| 刊行年月日 | 2006-06 |
| 言語 | eng |
| 内容記述 | Macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine essential for delayed hypersensitivity in vivo, and is involved in bronchiolitis obliterans and late rejection in lung transplantation. We tested here whether neutralization of MIF using anti-MIF antibody prevents such a response. We examined the MIF mRNA expression level and changes in allograft tracheal epithelium and intraluminal obstruction in a rat allograft model. Lewis rat (RT1l) underwent heterotopic tracheal transplantation from Brown Norway rats (RT1n) in the omentum. Anti-MIF antibody was injected in the peritoneum. Rats were divided into three groups (non-treated allograft, allograft treated with normal rabbit IgG and allograft treated with anti-MIF antibody). Implants were harvested on days 7 or 21 for histological analysis. MIF mRNA expression was higher in the allograft at days 7 and 21 than in the isograft. The epithelium in non-treated allograft was almost absent at day 7. The epithelial height in the anti-MIF-treated graft was higher than that in normal IgG-treated grafts. The intraluminal space was mostly replaced by granulation tissue at day 21 in the untreated group. The proportion of obliterans was lowest in the anti-MIF group, the second lowest in the untreated group and the third lowest in the normal IgG-treated grafts, and the difference was significant (p<0.001) between the first two groups. Our results indicate that anti-MIF antibody suppresses allogenic tracheal rejection. |
| キーワード | Lungtransplantation; Trachea; Macrophagemigrationinhibitoryfactor; Allograft; Chronicrejection; Bronchiolitisobliterans |
| 資料種別 | Departmental Bulletin Paper |
| 著者版フラグ | publisher |
| ISSN | 00016055 |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/612915 |
