| タイトル | EFFECTS OF BRAIN NATRIURETIC PEPTIDE-45, A CIRCULATING FORM OF RAT BNP, IN SPONTANEOUSLY HYPERTENSIVE RATS |
| その他のタイトル | 実験高血圧ラットにおけるbrain natriuretic peptide(BNP)の血圧ならびに水・電解質代謝に及ぼす影響 |
| 本文（外部サイト） | http://opac2.lib.miyazaki-u.ac.jp/webopac/bdyview.do?bodyid=BD00003868&elmid=Body&fname=kita1991_cover.pdf |
| 参考URL | http://hdl.handle.net/10458/4264 |
| 著者（日） | 北, 俊弘 |
| 発行日 | 2012-12-27 |
| 刊行年月日 | 1991-03 |
| 言語 | eng |
| 内容記述 | Recently rat brain natriuretic peptide-45(rat BNP-45) was isolated from rat heart, and was shown to be a circulating form of rat BNP. We investigated the effects of rat BNP-45 in anesthetized spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKY), and compared them with those of rat a-atrial natriuretic peptide(a-ANP). BNP-45 was a potent natriuretic and hypotensive agent in both strains. The effects were comparable with those of a-ANP, and were far greater than those of porcine BNP-26 reported previously. In SHR blood pressure decreased more than in WKY following injection of the highest dose (2.0 nmol/kg) of BNP-45 or a-ANP. However, WKY was more susceptible than SHR to BNP-45 for diuresis, natriuresis and urinary cGMP excretion. Moreover, a high dose of BNP-45 led to prolonged lowering of blood pressure and urinary cGMP excretion compared to a-ANP, and those features were prominent in WKY. On the other hand, BNP-45 disappeared more slowly than a-ANP, when the two peptides (2.0μg) were injected intravenously in WKY. Thus, rat BNP-45 and a-ANP had comparable hypotensive and natriuretic potency. However, the action and plasma half-life of rat BNP-45 were more prolonged. |
| キーワード | brain natriuretic peptide; atrial natriuretic peptide; blood pressure; natriuresis; metabolic clearance rate; rat |
| 資料種別 | Thesis or Dissertation |
| 著者版フラグ | author |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/738087 |
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