| タイトル | Geranylgeranylacetone prevents stress-induced decline of leptin secretion in mice |
| その他のタイトル | ゲラニルゲラニルアセトンはマウスにおいてストレスによるレプチン分泌の減少を防ぐ
GGA and leptin secretion |
| DOI | info:doi/10.2152/jmi.65.103 |
| 本文（外部サイト） | http://repo.lib.tokushima-u.ac.jp/files/public/11/111438/20190726141355705955/k3136_abstract_review.pdf
http://repo.lib.tokushima-u.ac.jp/files/public/11/111438/20190730172558405053/k3136_fulltext.pdf |
| 参考URL | http://repo.lib.tokushima-u.ac.jp/111438 |
| 著者（英） | Itai, Miki; Kuwano, Yuki; Nishikawa, Tatsuya; Rokutan, Kazuhito; Nishida, Kensei |
| 発行日 | 2018-02 |
| 発行機関など | Faculty of Medicine Tokushima University |
| 刊行物名 | The Journal of Medical Investigation |
| 巻 | 65 |
| 号 | 1-2 |
| 開始ページ | 103 |
| 終了ページ | 109 |
| 刊行年月日 | 2018-02 |
| 言語 | eng |
| 内容記述 | Geranylgeranylacetone (GGA) is a chaperon inducer that protects various types of cell and tissue against stress. We examined whether GGA modulated energy intake and expenditure under stressful conditions. After mice were untreated or treated orally with GGA (0.16 g per kg body weight per day) for 10 days, they were subjected to 2-h restraint stress once or once a day for 5 consecutive days. GGA administration did not affect corticosterone response to the stress. Restraint stress rapidly decreased plasma leptin levels in control mice. GGA significantly increased circulating leptin levels without changing food intake and prevented the stress-induced decline of circulating leptin. However GGA-treated mice significantly reduced food intake during the repeated stress, compared with control mice. GGA prevented the stress-induced decline of leptin mRNA and its protein levels in epidydimal adipose tissues. We also found that GGA decreased ghrelin mRNA expression in gastric mucosa before the stress, whereas GGA-treated mice recovered the ghrelin mRNA expression to the baseline level after the repeated stress. Leptin and ghrelin are now recognized as regulators of anxiety and depressive mood. Our results suggest that GGA may regulate food intake and relief stress-induced mood disturbance through regulating leptin and ghrelin secretions. |
| キーワード | Geranylgeranylacetone; stress; food intake; leptin; ghrelin |
| 資料種別 | Thesis or Dissertation |
| 著者版フラグ | ETD |
| ISSN | 13496867
13431420 |
| NCID | AA11166929
AA12022913 |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/930567 |
