| タイトル | Fludrocortisone: Role in Central Regulation of Fluid Balance |
| 本文（外部サイト） | http://hdl.handle.net/2060/19980211158 |
| 著者（英） | Dallman, M. F. |
| 著者所属（英） | California Univ. |
| 発行日 | 1996-01-01
1996 |
| 言語 | eng |
| 内容記述 | We have performed 7 experiments in rats on the effects of systemic treatment with fludrocortisone (9a-FF) given in a variety of doses over a variety of times, in the AM and in the PM. These experiments were designed to determine the best treatment protocol to use in the head-down rat model studies which were performed at NASA-Ames Research Center during the final year. The results of the experiments in non-stressed rats have been, on the whole, disappointing in that we have so far been unable to obtain direct evidence that the 9a-FF acts as a mineralocorticoid. In the ultimate experiments using control and suspended rats, we showed mineralocorticoid and glucocorticoid effects of 9aFF. However, suspension served in our rats as a chronic stressor when they were examined 5 d after the onset of treatment. |
| NASA分類 | Life Sciences (General) |
| レポートNO | NAS 1.26:206754
NASA/CR-1996-206754 |
| 権利 | No Copyright |
| URI | https://repository.exst.jaxa.jp/dspace/handle/a-is/98555 |
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